Genetic associations with coronary heart disease: Meta-analyses of 12 candidate genetic variants |
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| Authors: | Huadan Ye Xiaojing Li Lingyan Wang Qi Liao Leiting Xu Yi Huang Liming Xu Xuting Xu Cheng Chen Hangyu Wu Yanping Le Qiong Liu Meng Ye Changzheng Dong Shiwei Duan |
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| Institution: | 1. Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China;2. The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315000, China;3. Bank of Blood Products, Ningbo No. 2 Hospital, Ningbo, Zhejiang 315010, China |
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| Abstract: | AimsThe aim of this study was to evaluate the combined contribution of 12 genetic variants to the risk of coronary heart disease (CHD).MethodsThrough a comprehensive literature search for genetic variants involved in the CHD association study, we harvested a total of 10 genes (12 variants) for the current meta-analyses. These genes consisted of GPX1 (rs1050450), PPARD (rs2016520), ALOX15 (rs34210653), SELPLG (rs2228315), FCGR2A (rs1801274), CCL5 (rs2107538), CYP1A1 (rs4646903), TP53 (rs1042522), CX37 (rs1764391), and PECAM1 (rs668, rs12953, and rs1131012).ResultsA total of 45 studies among 23,314 cases and 28,430 controls were retrieved for the meta-analyses of 12 genetic variants. The results showed a significant association between the GPX1 rs1050450 polymorphism and CHD (odd ratio (OR) = 1.61, 95% confidence interval (CI) = 1.25–2.07, P = 0.0002). Other meta-analyses of the rest 11 variants suggested a lack of association with the risk of CHD.ConclusionOur results confirmed that GPX1 rs1050450 was associated with susceptibility to CHD in Chinese and Indian populations. |
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| Keywords: | (CHD) Coronary heart disease (OR) Odd ratio (95% CI) 95% confidence interval (GPx) Glutathione peroxidase (12/15-LOX) 12/15-lipoxygenases (CNKI) China National Knowledge Infrastructure (QC) Quality control (MAF) Minor allele frequency (GWAS) Genome-wide association studies |
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