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Association of adiponectin promoter variants with traits and clusters of metabolic syndrome in Arabs: Family-based study
Authors:F Zadjali  S AL-YahyaeeMO Hassan  S AlbarwaniRA Bayoumi
Institution:College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
Abstract:Plasma levels of adiponectin are decreased in type 2 diabetes, obesity and hypertension. Our aim was to use a family-based analysis to identify the genetic variants of the adiponectin (ADIPOQ) gene that are associated with obesity, insulin resistance, dyslipidemia and hypertension, among Arabs. We screened 328 Arabs in one large extended family for single nucleotide polymorphisms (SNPs) in the promoter region of the ADIPOQ gene. Two common SNPs were detected: rs17300539 and rs266729. Evidences of association between traits related to the metabolic syndrome and the SNPs were studied by implementing quantitative genetic association analysis. Results showed that SNP rs266729 was significantly associated with body weight (p-value = 0.001), waist circumference (p-value = 0.037), BMI (p-value = 0.015) and percentage of total body fat (p-value = 0.003). Up to 4.1% of heritability of obesity traits was explained by the rs266729 locus. Further cross-sectional analysis showed that carriers of the G allele had significantly higher values of waist circumference, BMI and percentage of total body fat (p-values 0.014, 0.004 and 0.032, respectively). No association was detected between SNP rs266729 and other clusters of metabolic syndrome or their traits except for HOMA-IR and fasting plasma insulin levels, p-values 0.035 and 0.004, respectively. In contrast, both measured genotype and cross-sectional analysis failed to detect an association between the SNP rs17300539 with traits and clusters of metabolic syndrome. In conclusion, we showed family-based evidence of association of SNP rs266729 at ADIPOQ gene with traits defining obesity in Arab population. This is important for future prediction and prevention of obesity in population where obesity is in an increasing trend.
Keywords:ADIPOQ  adiponectin  BMI  body mass index  DBP  diastolic blood pressure  DNA  deoxyribonucleic acid  dNTPs  dideoxynucleotides  HDL  high density lipoprotein  HOMA-IR  homeostasis model of assessment-insulin resistance  IDF  International Diabetes Federation  LDL  low density lipoprotein  LOD  logarithm (base 10) of odds  MGA  measured genotype analysis  PCR  polymerase chain reaction  PPARγ  peroxisome proliferator activated receptor gamma  QTL  quantitative trait locus  SBP  systolic blood pressure  SNP  single nucleotide polymorphism  SOLAR  Sequential Oligogenic Linkage Analysis Routines  T2DM  type 2 diabetes mellitus  TG  triglycerides  VLDL  very low density lipoprotein
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