Haplotype study of the CYP4A11 gene and coronary artery disease in Han and Uygur populations in China |
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Authors: | Zhenyan Fu Hong Yang Yitong Ma Ding Huang Xiang Xie Yingying Zheng Qing Zhu Tomohiro Nakayama |
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Affiliation: | 1. Department of Cardiovascular Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China;2. Division of Laboratory Medicine, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan |
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Abstract: | BackgroundCYP4A11 converts arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE), which has a crucial role in the modulation of cardiovascular homeostasis. We assessed the association between the human CYP4A11 gene and coronary artery disease (CAD) in Han and Uygur populations in China.Methods and ResultsIn the Han population, 361 CAD patients and 315 controls were genotyped for four single-nucleotide polymorphisms (SNPs) of the human CYP4A11 gene (rs9332978, rs4660980, rs3890011, rs1126742). In the Uygur population, 331 CAD patients and 182 controls were genotyped for the same four SNPs. Data were assessed via haplotype-based case–control studies. For the Han population, the significance of the recessive model of SNP3 (GG vs. CC+GC) between CAD patients and control subjects was retained after adjustment for EH, DM and smoking (for men, 95% CI: 1.173–3.013, P = 0.009). The G-G-T haplotype in CAD was significantly higher than that in the control group (P = 0.037). In the Uygur population, neither the distribution of genotypes and alleles for the four SNPs nor the distribution of haplotypes constructed with the same three SNPs showed a significant difference between CAD and control subjects.ConclusionsThe GG genotype of rs3890011 and the G-G-T haplotype in the CYP4A11 gene could be a useful genetic marker of CAD in Han populations in China. |
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Keywords: | 20-HETE, 20-hydroxyeicosatetraenoic acid CAD, coronary artery disease SNPs, single-nucleotide polymorphisms EH, essential hypertension DM, diabetes mellitus CYP, the cytochrome p450 EET, epoxyeicosatrienoic acid MI, myocardial infarction SBP, systolic blood pressure DBP, diastolic blood pressure UN, urea nitrogen Cr, creatinine Glu, glucose TC, total cholesterol TG, triglyceride LDL, low-density lipoprotein HDL, high-density lipoprotein LD, linkage disequilibrium EM, expectation maximization PGI2, prostacyclin VSMCs, vascular smooth muscles cells TxA2, thromboxaneA2 ABI, appliedbiosystems SDS, sequence detection systems CVD, cardiovascular disease |
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