ZBTB38 gene polymorphism associated with body measurement traits in native Chinese cattle breeds |
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Authors: | Yongfeng Liu Linsen Zan Yaping Xin Wanqiang Tian Linqiang Li Hongcheng Wang |
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Institution: | 1. College of Food Engineering and Nutritional Science, Shaanxi Normal University, 710062, Xi''an, Shaanxi, PR China;2. College of Animal Science and Technology, Northwest A & F University, Yangling 712100, Shaanxi, PR China |
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Abstract: | Body measurement traits, influenced by genes and environmental factors, play numerous important roles in the value assessment of productivity and economy. In this study, we investigated the association between genetic polymorphisms of the zinc finger and BTB domain containing 38 gene (ZBTB38) and body measurement traits in native Chinese cattle. Using direct DNA sequencing in 423 individuals of 8 different cattle subpopulations, 9 novel polymorphisms were identified for genotyping within 647 bp region of exon 1 of ZBTB38. Linkage disequilibrium and association analysis revealed that two coding exon polymorphisms (2323 G>A and 2325 C>T polymorphisms), missense mutations valine GTC(T) to isoleucine ATC(T), were associated with body length (BL), withers height (WH) and rump length (RL). Furthermore, the analysis of 2323 G>A and 2325 C>T SNP markers shows that there are significant effects on the BL (P = 0.0488), WH (P = 0.0044) and RL (P = 0.0314) in the total population. These results clearly suggest that the ZBTB38 gene is among the target genes for body measurement traits in bovine breeding, and provide data for establishment of an animal model using cattle to study big animal body type. |
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Keywords: | ZBTB38 zinc finger and BTB domain containing 38 CtBP C-terminal binding protein BTB broad complex tramtrack and bric-a-brac CIBZ murine CtBP-interacting BTB zinc finger protein ZENON zinc finger gene expressed in neurons HDAC histone deacetylase IGF insulin-like growth factor BL body length WH withers height HH hip height RL rump length HW hip width CD chest depth HG heart girth PBW pin bone width bp base pairs MAS marker-assisted selection PCR polymerase chain reaction SNP single nucleotide polymorphism HWE Hardy&ndash Weinberg equilibriums LD linkage disequilibrium RFLP restriction fragment length polymorphism PIC polymorphism information content CDS coding sequence nt nucleotides GWA genome wide association |
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