Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotypes in Follicular Lymphoma patients: Results of a pilot study |
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| Authors: | Roy Khalaf Rouba Hoteit Soha Yazbek Nady El Hajj Zaher Otrock Sarah Khansa Amira Sabbagh Dina Shammaa Rami Mahfouz |
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| Institution: | 1. Department of Biology, Lebanese American University, Byblos, Lebanon;2. Department of Pathology & Laboratory Medicine, American University of Beirut Medical Center, Lebanon;3. Faculty of Health Sciences and Department of Biochemistry, American University of Beirut Medical Center, Lebanon |
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| Abstract: | AimsThe Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotype profiling in Follicular Lymphoma has not been reported before in the literature.Materials and methodsDNA extracted from 20 Follicular Lymphoma patients and 62 healthy controls was analyzed for KIR genotyping using a polymerase chain reaction/sequence specific primers technique (PCR/SSP) for the presence of 16 KIR gene and pseudogene loci.ResultsThe AA, AB, and BB genotype frequencies were, respectively, 20%, 60% and 20% with an A:B ratio of 1:1. KIR 2DL4, KIR 3DL2, KIR 3DL3, and KIR 3DP1*003 were presented in all individuals. No significant difference between patients and controls was detected.ConclusionKIR genotyping profile does not seem to be associated with Follicular Lymphoma. The results presented in this pilot research represent the first international report about this important clinical entity. |
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| Keywords: | KIR Killer Cell Immunoglobulin-like Receptors PCR Polymerase chain reaction SSP Sequence specific primers NHL Non-Hodgkin's lymphoma Ig Immunoglobulin FL Follicular Lymphoma NK Natural killer HLA Human leukocyte antigens MHC Major histocompatibility complex ITIM Immunoreceptor tyrosine based inhibition motifs HSTCL Hepatosplenic T-cell lymphoma UV Ultraviolet |
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