Associations of the PTEN − 9C>G polymorphism with insulin sensitivity and central obesity in Chinese |
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Authors: | Qiu Yang,Hongyi Cao,Shugui Xie,Yuzhen Tong,Qibo Zhu,Fang Zhang,Qingguo Lü ,Yan Yang,Daigang Li,Mei Chen,Changyong Yu,Wei Jin,Yuquan Yuan,Nanwei Tong |
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Affiliation: | 1. Division of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, Sichuan, China;2. Division of Endocrinology and Metabolism, Chengdu Fifth People''s Hospital, Chengdu, Sichuan, China;3. Chengdu Aerospace Hospital, Chengdu, Sichuan, China;4. Department of Clinical Medicine, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China;5. Chengdu Yincao Community Hospital, Chengdu, Sichuan, China |
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Abstract: | BackgroundPhosphatase and tensin homolog on chromosome 10 gene (PTEN) is known as a tumor-suppressor gene. Previous studies demonstrated that PTEN dysfunction affects the function of insulin. However, investigations of PTEN single nucleotide polymorphisms (SNPs) and IR-related disease associations are limited. The aim of the present study was to investigate whether its polymorphism could be involved in the risk of metabolic syndrome (MetS).MethodsThe genotype frequency of PTEN − 9C>G polymorphism was determined by using a Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry (MALDI-TOF MS) method in 530 subjects with MetS and 202 healthy control subjects of the Han Ethnic Chinese population in a case–control analysis.ResultsThe PTEN − 9C>G polymorphism was not associated with MetS or its hyperglycemia, hypertension and hypertriglyceridemia components. In the control individuals aged < 60 years or ≥ 60 years, the CG genotype individuals had lower insulin sensitivity than CC individuals (P < 0.05). In the < 60-year-old MetS group and normal glucose tolerance (NGT) subgroup, the CG individuals had lower insulin sensitivity and higher waist circumference (WC) and waist-height-ratio (WHtR) than CC individuals (P < 0.05). Multiple linear regression analysis showed that the PTEN polymorphism (P = 0.001) contributed independently to 4.2% (adjusted R2) of insulin sensitivity variance (estimated by Matsuda ISI), while age (P = 0.004), gender (P = 0.000) and the PTEN polymorphism (P = 0.032) contributed independently to 5.6% (adjusted R2) of WHtR variance.ConclusionsThe CG genotype of PTEN − 9C>G polymorphism was not associated with MetS and some of its components as well. However, it may not only decrease insulin sensitivity in the healthy control and MetS in pre-elderly or NGT subjects, but may also increase the risk of central obesity among these MetS individuals. |
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Keywords: | PTEN, phosphatase and tensin homolog on chromosome 10 SNP, single nucleotide polymorphism MetS, metabolic syndrome NGT, normal glucose tolerance IR, insulin resistance CVD, cardiovascular disease PD, prediabetes DM, type 2 diabetes mellitus BMI, body mass index WC, waist circumference WHtR, waist circumference/height Matsuda ISI, Matsuda insulin sensitivity index HOMA-IR, homeostasis model assessments of insulin resistance HOMA-β, homeostasis model assessments of β-cell function PI3K, phosphatidylinositol (PI) 3-kinase PIP2, phosphatidylinositol-4,5-bisphosphate PIP3, phosphatidylinositol-3,4,5-trisphosphate PKA, protein kinase A PKC, protein kinase C MMAC1, multiple advanced cancers 1 TEP1, TGFβ-regulated and epithelial cell-enriched phosphatase 1 NAFLD, nonalcoholic fatty liver disease OGTT, oral glucose tolerance test HbA1c, glycated hemoglobin MALDI-TOF MS, Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry ANOVA, analysis of variance OR, odds ratio CI, confidence interval |
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