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Gene expression profile of aquaporin 1 and associated interactors in malignant pleural mesothelioma |
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| Authors: | Rajesh Jagirdar Evgeniy I Solenov Chrissi Hatzoglou Paschalis-Adam Molyvdas Konstantinos I Gourgoulianis Sotirios G Zarogiannis |
| Institution: | 1. GeneClick.org, Hyderabad, India;2. Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia;3. Novosibirsk State University, Novosibirsk, 630090, Russia;4. Department of Physiology, University of Thessaly Medical School, BIOPOLIS, Larissa 41110, Greece;5. Department of Respiratory Medicine, University of Thessaly Medical School, BIOPOLIS, Larissa 41110, Greece |
| Abstract: | Overexpression of AQP1 has recently been shown to be an independent prognostic factor in pleural mesothelioma favoring survival. This paper presents a data mining and bioinformatics approach towards the evaluation of the gene expression profile of AQP1 in malignant pleural mesothelioma and of AQP1 associated markers in the context of mesothelioma disease phenotype, CDKN2A gene deletion, sex and asbestos exposure. The data generated were thus again subjected to differential expression profile analysis. Here we report that AQP1 is overexpressed in epithelioid mesothelioma and identify TRIP6 and EFEMP2 as candidate genes for further investigation in mesothelioma. |
| Keywords: | AQP1 aquaporin-1 ARCL1B autosomal recessive cutis laxa type 1B CCDC85B coiled-coil domain containing 85B CDKN2A cyclin-dependent kinase inhibitor 2A ECM extracellular matrix EFEMP2 EGF containing fibulin-like extracellular matrix protein 2 FDR false discovery rate GO gene ontology KCTD17 potassium channel tetramerization domain containing 17 KRTAP4-12 keratin associated protein 4&ndash 12 MDFI MyoD family inhibitor MPM malignant pleura mesothelioma TRIP6 thyroid hormone receptor interactor 6 |
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