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Association study on MTHFR polymorphisms and meningioma in northern China |
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| Authors: | Ruiyan Li Rui Wang Yongli Li Xianfeng Li Yan Feng Yongzhe Li Chuanlu Jiang |
| Institution: | 1. The Third Ward of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China;2. The Third Ward of Neurology Department, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China;3. The First Ward of Neurosurgery, the Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
| Abstract: | BackgroundMeningioma is the second most common primary tumor of the central nervous system, and multiple genetic and environmental factors contribute to its etiology. Methylene tetrahydrofolate reductase (MTHFR) is a pivotal enzyme in folate metabolism. We conducted a case–control study to investigate the association of the MTHFR gene and meningioma in a Han population in northern China.MethodsWe genotyped two SNPs (C677T and A1298C) using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). In this study 317 meningioma patients were compared to 320 normal controls. Data were analyzed by SPSS 13.0 and HaploView software.ResultsWe found a significant difference in the frequency distribution of 677CC and 677TT between cases and control groups; another SNP exhibited no differences in any genotype between the two cohorts.ConclusionThe results revealed that variations of the MTHFR gene were associated with meningioma; this finding indicates that the MTHFR gene potentially plays an important role in the pathogenesis of meningioma in the Northern Chinese Han population. |
| Keywords: | MTHFR methylene tetrahydrofolate reductase MTHF methylenetetrahydrofolate SNP single nuclear polymorphism CNS central nervous system PCR-RFLP polymerase chain reaction-restriction fragment length polymorphism HWE Hardy&ndash Weinberg equilibrium |
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