The skeleton in the closet |
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| Authors: | Frederick S. Kaplan |
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| Affiliation: | Isaac & Rose Nassau Professor of Orthopaedic Molecular Medicine, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA |
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| Abstract: | The origins of fibrodysplasia ossificans progressiva (FOP) in human history are unknown but the condition has been well described since Freke's account in 1740. Important contributions by physicians and scientists in the past two and a half centuries have converged on the remarkable skeleton of Harry Eastlack at The Mutter Museum of The College of Physicians in Philadelphia. |
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| Keywords: | FOP, fibrodysplasia ossificans progressiva BMP, bone morphogenetic protein ACVR1/ALK2, activin A receptor, type I/activin receptor-like kinase 2 |
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