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Frequency of LCT-13910C/T and LCT-22018G/A single nucleotide polymorphisms associated with adult-type hypolactasia/lactase persistence among Israelis of different ethnic groups |
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| Authors: | Maytal Raz Yael Sharon Baruch Yerushalmi Ruth Birk |
| Institution: | 1. Nutrition Department, Faculty of Health Science, Ariel University Center, Israel;2. Pediatric Gastroenterology Unit, Soroka University Medical Center, Beer-Sheva, Israel |
| Abstract: | Primary lactase deficiency (PLD), the physiological decline of lactase, is associated with the LC-13910C/T and LCT-22018G/A polymorphisms. PLD is the most common phenotype in humans and varies widely as a function of ethnicity. Israel is a multiethnic country. We analyzed the genetic frequencies of PLD in different Israeli ethnicities. |
| Keywords: | HBT hydrogen breathe testing LCT lactase gene LTT lactose tolerance test PCR polymerase chain reaction PLD primary lactase deficiency RFLP restriction fragment length polymorphism analysis SNP single nucleotide polymorphism |
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