Cox-2 gene variants in migraine |
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Authors: | Selcuk Dasdemir Yilmaz Cetinkaya Mehmet Gencer Elif Ozkok Makbule Aydin Bedia Cakmakoglu |
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Affiliation: | 1. Department of Molecular Medicine, Institute of Experimental Medicine Research, Istanbul University, Istanbul, Turkey;2. Department of Neurology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey;3. Department of Neuroscience, Institute of Experimental Medicine Research, Istanbul University, Istanbul, Turkey |
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Abstract: | PurposeMigraine is a multifactorial and complex disorder, and any clear diagnostic marker to assess the status of the migraineurs has not been established, yet. Nonsteroidal anti-inflammatory drugs reduce production of prostanoids including PGE2 by inhibiting COX-1 and/or COX-2, and thereby suppress inflammatory pain in patients suffering from rheumatoid arthritis, osteoarthritis, and migraine. Thus, COX-2 regulation is important in the pathogenesis and treatment of migraine. We prospectively investigated COX-2-765G → C and COX-2-1195A → G gene polymorphisms which may account for an increased risk of migraine.MethodsThe present analyses are based on 144 case subjects with migraine disease and 123 non-case subjects. Genotyping of COX-2 gene polymorphisms (COX-2-765G → C, COX-2-1195A → G) was detected by PCR-RFLP.ResultsWe, for the first time, demonstrated positive association of COX-2 gene variants with an increased risk for development of migraine. Carriers of COX-2-765 C + genotype in controls were higher than in the patients (57.7% and 36.1% respectively; P < 0.0001) and the frequencies of G + genotype in patients were higher than in the controls (97.9% and 88.6% respectively; P: 0.002). In addition, frequencies of COX-2-765 GG and GC genotypes in patients were higher than in the controls (P < 0.0001, P < 0.0001 respectively). It seems that COX-2-765 G + genotype had increased and COX-2-765 C + genotype had decreased risk for migraine. In COX-2-1195 polymorphism only AG genotype was statistically significantly different in patients than in the controls (P < 0.05).ConclusionsOur findings have suggested that COX-2-765 G + genotype could facilitate the development of migraine disease. |
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Keywords: | MA, migraine with aura MO, migraine without aura ICHDII, International Criteria for Headache Disorders COX, cyclooxygenase PGE2, prostaglandin E2 NSAIDs, nonsteroidal anti-inflammatory drugs IHS, International Headache Society PCR, polymerase chain reaction RFLP, restriction fragment length polymorphism CI, confidence intervals OR, odds ratio |
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