The genetic polymorphisms of cathepsin S were associated with metabolic disorders in a Chinese Han population |
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Authors: | Zejin Ou Guanghai Wang Qiang Li Zuliang Ma Danmiao Lin Meng Dai Fei Zou |
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Institution: | 1. Department of Occupational Health and Occupational Medicine, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou, China;2. Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China;3. Health Management Center, Nanfang Hospital, Southern Medical University, Guangzhou, China |
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Abstract: | Cathepsin S (CTSS) played an important role in the etiology of cardiovascular disease and metabolic syndrome. Few studies had been reported on the association between the polymorphisms of CTSS and metabolic disorders in Asian population. Therefore we explored the association between the polymorphisms of CTSS and metabolic disorders in a Chinese Han population. The subjects were a Chinese Han cohort with 1160 participants, and the genotyping was performed with PCR-RFLP. Polymorphism rs16827671 was associated with BMI and serum total cholesterol (P = 0.001; P = 0.02, respectively). Subjects with CT genotype of rs16827671 had a higher risk of hypercholesterolemia (OR = 1.64, 95% CI: 1.15–2.33, P = 0.006) compared with TT genotype. Subjects with AG genotype of rs11576175 had lower risks of hypertriglyceridemia and borderline hypercholesterolemia (OR = 0.52, 95% CI: 0.36–0.73, P = 0.0001; OR = 0.52, 95% CI: 0.35–0.77, P = 0.001, respectively) compared with GG genotype. Compared with the haplotype TG, haplotype TA had a lower risk of hypertriglyceridemia and a higher risk of borderline hypercholesterolemia (OR = 0.62, 95% CI: 0.44–0.88, P = 0.002; OR = 1.59, 95% CI: 1.10–2.31, P = 0.008, respectively), and haplotype CA had a lower risk of hypercholesterolemia (OR = 0.35, 95% CI: 0.18–0.68, P = 0.002). In conclusion, we found that the genetic polymorphisms of CTSS were associated with metabolic disorders in a Chinese Han population, which would enrich the knowledge on genetic mechanisms of the pathogenesis of metabolic disorders. |
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Keywords: | CTSS cathepsin S BMI body mass index TG triglyceride TC total cholesterol HDL high-density lipoprotein NCEP-ATP III National Cholesterol Education Program Adult Treatment Panel III HWE Hardy&ndash Weinberg equilibrium PCR-RFLP polymerase chain reaction-restriction fragment length polymorphism OR odds ratio CI confidence interval ECM extracellular matrix GWAS genome-wide association study |
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