Genetic variability of glutathione S-transferase enzymes in human populations: Functional inter-ethnic differences in detoxification systems |
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| Authors: | Renato Polimanti Cinzia Carboni Ilenia Baesso Sara Piacentini Andrea Iorio Gian Franco De Stefano Maria Fuciarelli |
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| Affiliation: | 1. Department of Biology, University of Rome “Tor Vergata”, Rome, Italy;2. Clinical Pathophysiology Center, AFaR, “San Giovanni Calibita” Fatebenefratelli Hospital, Rome, Italy |
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| Abstract: | Glutathione S-Transferase enzymes (GSTs) constitute the principal Phase II superfamily which plays a key role in cellular detoxification and in other biological processes. Studies of GSTs have revealed that genetic polymorphisms are present in these enzymes and that some of these are Loss-of-Function (LoF) variants, which affect enzymatic functions and are related to different aspects of human health. |
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| Keywords: | GSTs, Glutathione S-Transferases LoF, Loss-of-Function MAPEG, Membrane-Associated Proteins involved in Eicosanoid and Glutathione metabolism GSTA, GST alpha class GSTM, GST mu class GSTP, GST pi class GSTT, GST theta class GSTK, GST kappa class GSTZ, GST zeta class GSTO, GST omega class CNVs, copy number variants X2, chi-square test LD, Linkage Disequilibrium ASW, African ancestry in Southwest USA CEU, Utah residents with Northern and Western European ancestry from the CEPH collection CHB, Han Chinese in Beijing, China CHD, Chinese in Metropolitan Denver, Colorado GIH, Gujarati Indians in Houston, Texas JPT, Japanese in Tokyo, Japan LWK, Luhya in Webuye, Kenya MEX, Mexican ancestry in Los Angeles, California MKK, Maasai in Kinyawa, Kenya TSI, Tuscan in Italy YRI, Yoruban in Ibadan, Nigeria IL-1β, interleukin-1β |
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