Genetic variability of glutathione S-transferase enzymes in human populations: Functional inter-ethnic differences in detoxification systems期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Genetic variability of glutathione S-transferase enzymes in human populations: Functional inter-ethnic differences in detoxification systems

Authors:	Renato Polimanti Cinzia Carboni Ilenia Baesso Sara Piacentini Andrea Iorio Gian Franco De Stefano Maria Fuciarelli

Institution:	1. Department of Biology, University of Rome “Tor Vergata”, Rome, Italy;2. Clinical Pathophysiology Center, AFaR, “San Giovanni Calibita” Fatebenefratelli Hospital, Rome, Italy

Abstract:	Glutathione S-Transferase enzymes (GSTs) constitute the principal Phase II superfamily which plays a key role in cellular detoxification and in other biological processes. Studies of GSTs have revealed that genetic polymorphisms are present in these enzymes and that some of these are Loss-of-Function (LoF) variants, which affect enzymatic functions and are related to different aspects of human health.

Keywords:	GSTs Glutathione S-Transferases LoF Loss-of-Function MAPEG Membrane-Associated Proteins involved in Eicosanoid and Glutathione metabolism GSTA GST alpha class GSTM GST mu class GSTP GST pi class GSTT GST theta class GSTK GST kappa class GSTZ GST zeta class GSTO GST omega class CNVs copy number variants X² chi-square test LD Linkage Disequilibrium ASW African ancestry in Southwest USA CEU Utah residents with Northern and Western European ancestry from the CEPH collection CHB Han Chinese in Beijing China CHD Chinese in Metropolitan Denver Colorado GIH Gujarati Indians in Houston Texas JPT Japanese in Tokyo Japan LWK Luhya in Webuye Kenya MEX Mexican ancestry in Los Angeles California MKK Maasai in Kinyawa Kenya TSI Tuscan in Italy YRI Yoruban in Ibadan Nigeria IL-1β interleukin-1β
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