| 生物活性肽——蛋氨酸脑啡肽的免疫 |
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| 引用本文： | 冯鹏辉,单风平. 生物活性肽——蛋氨酸脑啡肽的免疫[J]. 微生物学杂志, 2015, 0(6): 100-104 |
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| 作者姓名： | 冯鹏辉 单风平 |
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| 作者单位： | 中国医科大学 基础医学院 免疫学教研室，辽宁 沈阳 110122,中国医科大学 基础医学院 免疫学教研室，辽宁 沈阳 110122 |
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| 摘 要： | 源自肾上腺前脑啡肽原的具有吗啡样生物活性的内源性神经肽蛋氨酸脑啡肽(methionine enkephalin，MENK)，由５个氨基酸残基Tyr Gly Gly Phe Met组成，与G蛋白偶联的７次跨膜特异性受体结合后发挥不同的生物学功能。目前，对蛋氨酸脑啡肽的作用及其机制研究已经取得了很大进展。本文就MENK对于免疫系统的调节及其对肿瘤、自身免疫病、艾滋病等免疫系统相关疾病的治疗作用予以综述。
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| 关 键 词： | 蛋氨酸脑啡肽；阿片生长因子；阿片肽；阿片生长因子受体；免疫调节 |
Advances in the Research of the Immunomodulatory effects of Methionine Enkephalin |
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| FENG Peng-hui and SHAN Feng-ping. Advances in the Research of the Immunomodulatory effects of Methionine Enkephalin[J]. Journal of Microbiology, 2015, 0(6): 100-104 |
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| Authors: | FENG Peng-hui and SHAN Feng-ping |
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| Affiliation: | Teach. &Res. Div. of Immunol., Coll. of Basic Med.Sci., China Med. Uni, Shenyang 110122 and Teach. &Res. Div. of Immunol., Coll. of Basic Med.Sci., China Med. Uni, Shenyang 110122 |
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| Abstract: | Preproenkephalin derived from adrenal gland possessed bioactivity of morphine like substance of endogenous neuropeptide methionine enkephalin (MENK), is composed of five amino acid residues Tyr Gly Gly Phe Met. It brought into play of different bio functions after coupled with seven transmembrane specific domain G protein coupled receptor. At present, much progress has been made in the research of the modulatory effect and mechanism of methionine enkephalin. The regulation on immune system of MENK and the therapy effects of antitumor, autoimmune diseases, AIDS, and other immune-related diseases were summarized in this paper. |
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| Keywords: | methionine enkephalin (MENK) opioid growth factor opioid peptide opioid growth factor receptor immunoregulation |
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