自噬和铁死亡的相互联系

自噬是一个保守的细胞内降解系统,在细胞死亡中起着双重作用,可以为细胞在营养缺乏条件下提供一些必要的营养物质促进细胞存活,但是自噬过度发生会导致细胞内一些正常组分被降解从而加速细胞死亡.铁死亡是一种新的细胞死亡调控形式,主要依赖于铁的积累和脂质过氧化.铁死亡在细胞形态、生物化学特征和所涉及的调控因子上都与自噬以及其他类型...

The Crosstalk between Autophagy and Ferroptosis

Autophagy and ferroptosis are two forms of RCD(regulated cell death).Autophagy supplies nutrients for the synthesis of essential proteins during starvation,and thus helps to extend cell survival.However,excess autophagy can destroy essential cellular components and lead to cell death.Ferroptosis is a newly identified RCD which depends on the iron accumulation and lipid peroxidation.The main features of ferroptosis are significantly distinguished from autophagy in terms of morphology,biochemistry and genetics.Recently,extensive evidences have shown that there is a crosstalk between these two forms of RCDs.Studies have demonstrated that activation of ferroptosis is dependent on the induction of autophagy.Additionally,many ferroptosis regulators have been identified as potential regulators of autophagy.This review highlights the crosstalk mechanisms between autophagy and ferroptosis at the molecular level.