| 固有淋巴细胞在脂质代谢中的研究进展 |
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| 引用本文： | 何安芳,徐薇,吴梦梦,蒋培城,杨冬琴. 固有淋巴细胞在脂质代谢中的研究进展[J]. 中国细胞生物学学报, 2021, 0(1): 31-38 |
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| 作者姓名： | 何安芳 徐薇 吴梦梦 蒋培城 杨冬琴 |
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| 作者单位： | 复旦大学附属华山医院消化科;复旦大学基础医学院免疫学系;复旦大学附属金山医院消化内科 |
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| 基金项目： | 国家自然科学基金(批准号:81770579)资助的课题。 |
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| 摘 要： | 由于世界范围内营养条件和生活方式的变化,肥胖及其相关的代谢性疾病已成为当前威胁人类健康的重要因素之一.在能量摄取和消耗以及体内脂肪储存、分解和脂肪组织重塑的研究中,人们逐渐认识到脂质过量及异位堆积将导致代谢组织处于慢性炎症状态,这开启了肥胖相关组织炎症研究的新方向.固有淋巴细胞(innate lymphoid cell...
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| 关 键 词： | 肥胖 代谢性疾病 ILCs 脂质代谢 能量代谢 |
Research Advances on Innate Lymphoid Cells in Lipid Metabolism |
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| HE Anfang,XU Wei,WU Mengmeng,JIANG Peicheng,YANG Dongqin. Research Advances on Innate Lymphoid Cells in Lipid Metabolism[J]. , 2021, 0(1): 31-38 |
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| Authors: | HE Anfang XU Wei WU Mengmeng JIANG Peicheng YANG Dongqin |
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| Affiliation: | (Department of Digestive Diseases of Huashan Hospital,Fudan University,Shanghai 200040,China;Department of Immunology,School of Basic Medical Sciences,Fudan University,Shanghai 200030,China;Department of Gastroenterology,Jinshan Hospital,Fudan University,Shanghai 200540,China) |
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| Abstract: | Obesity and obesity-associated metabolic diseases have become worldwide health problems as a result of changes in nutritional conditions and lifestyles.A series of studies on energy storage and consumption have demonstrated that excess and ectopic accumulation of lipids promote chronic inflammation and remodeling of metabolic tissues,which leads to a new direction of metabolic diseases and immunity.ILCs(innate lymphoid cells)are newly discovered tissue-resident immune cells.ILCs have been reported to play a role in the maintenance of steady-state energy metabolism and the development of chronic inflammation in obese tissues,which makes them the rising star in the field of lipid metabolism.This review will discuss the research advances in chronic inflammation of adipose tissue under obesity highlighting the role of ILCs in energy metabolism and the molecular mechanism of regulation,thus providing scientific support for the transformation of ILCs in the treatment of metabolic diseases. |
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| Keywords: | obesity metabolic diseases ILCs lipid metabolism energy metabolism |
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