L-arginine stimulates insulin secretion from the pancreas of normal and diabetic rats |
| |
Authors: | Adeghate E Ponery A S El-Sharkawy T Parvez H |
| |
Institution: | (1) Department of Human Anatomy and, AE;(2) Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates, AE;(3) Unite de Neuropharmacologie, Institute Alfred Fessard de Neuroscience, CNRS, Paris, France, FR |
| |
Abstract: | Summary. Several reports have shown that nitric oxide (NO) stimulates glucose-induced insulin secretion in the pancreas of normal
rat but the effect of L-arginine (a NO donor) on insulin secretion from the pancreas of diabetic pancreas is unknown. Fragments
of pancreatic tissue from normal and diabetic rats were incubated for 45 min in Krebs solution containing 100 mM L-arginine.
The supernatant was subsequently analyzed for the insulin content using radioimmunoassay technique. L-arginine evoked large
increases in insulin secretion from the pancreas of diabetic rat. The insulin secreted from the pancreas of diabetic rat was
numerically but not significantly lower compared to that of normal rat pancreas. In conclusion, L-arginine, a nitric oxide
donor stimulates insulin secretion from the pancreas of diabetic rats.
Received October 3, 2000 Accepted November 10, 2000 |
| |
Keywords: | : Amino acids Insulin secretion Radioimmunoassay L-Arginine NO Pancreas Diabetes mellitus Rat |
本文献已被 PubMed SpringerLink 等数据库收录! |
|