Pooling serum samples may lead to loss of potential biomarkers in SELDI-ToF MS proteomic profiling期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Pooling serum samples may lead to loss of potential biomarkers in SELDI-ToF MS proteomic profiling

Authors:	S Tariq Sadiq Dan Agranoff

Affiliation:	(1) Centre for Infection, Cellular & Molecular Medicine, St George's University of London, Cranmer Terrace, SW17 London, UK;(2) Department of Infectious Diseases and Immunity, Imperial College London (Hammersmith campus), Commonwealth Bldg, Du Cane Rd, W12 ONN London, UK

Abstract:	Background High throughput proteomic technology offers promise for the detection of disease biomarkers and proteomic signature patterns but biomarker discovery studies can be limited by cost factors when large sample size numbers are required. Pooling sera or plasma samples from disease cases potentially offers a solution to cost implications by reducing the standard errors of mass to charge values. Surface enhanced laser desorption/ionization time of flight (SELDI-ToF) mass spectra obtained from individual and pooled sera from invasive aspergillosis cases and controls were compared.

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