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Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors |
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| Authors: | Thomas J Lukas Haixi Miao Lin Chen Sean M Riordan Wenjun Li Andrea M Crabb Alexandria Wise Pan Du Simon M Lin M Rosario Hernandez |
| Affiliation: | (1) Department of Molecular Pharmacology and Biological Chemistry, Feinberg School of Medicine, Northwestern University, E Chicago Ave, Chicago, IL, 60611, USA;(2) Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, E Chicago Ave, Chicago, IL 60611, USA;(3) Department of Biology, City College of New York, Convent Ave, New York, NY 10031, USA;(4) Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, E Chicago Ave, Chicago, IL, USA |
| Abstract: | BackgroundEpidemiological and genetic studies indicate that ethnic/genetic background plays an important role in susceptibility to primary open angle glaucoma (POAG). POAG is more prevalent among the African-descent population compared to the Caucasian population. Damage in POAG occurs at the level of the optic nerve head (ONH) and is mediated by astrocytes. Here we investigated differences in gene expression in primary cultures of ONH astrocytes obtained from age-matched normal and glaucomatous donors of Caucasian American (CA) and African American (AA) populations using oligonucleotide microarrays. |
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