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A general modeling and visualization tool for comparing different members of a group: application to studying tau-mediated regulation of microtubule dynamics |
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| Authors: | Arnab Bhattacharya Sasha Levy Adria LeBoeuf Michelle Gaylord Leslie Wilson Ambuj K Singh Stuart C Feinstein |
| Affiliation: | (1) Department of Computer Science and Engineering, Indian Institute of Technology (I.I.T.), Kanpur, India;(2) Department of Computer Science, University of California at Santa Barbara, Santa Barbara, CA, USA;(3) Center for Comparative Functional Genomics, New York University, New York, NY, USA;(4) Howard Hughes Medical Institute and Laboratory of Sensory Neuroscience, Rockefeller University, New York, NY, USA;(5) Department of Molecular, Cellular and Developmental Biology, University of California at Santa Barbara, Santa Barbara, CA, USA |
| Abstract: | BackgroundInnumerable biological investigations require comparing collections of molecules, cells or organisms to one another with respect to one or more of their properties. Almost all of these comparisons are performed manually, which can be susceptible to inadvertent bias as well as miss subtle effects. The development and application of computer-assisted analytical and interpretive tools could help address these issues and thereby dramatically improve these investigations. |
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