IDEA: Interactive Display for Evolutionary Analyses |
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| Authors: | Amy Egan Anup Mahurkar Jonathan Crabtree Jonathan H Badger Jane M Carlton Joana C Silva |
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| Affiliation: | (1) Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA;(2) The J. Craig Venter Institute, San Diego, CA 92121, USA;(3) Department of Medical Parasitology, New York University School of Medicine, New York, NY 10010, USA;(4) Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA |
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| Abstract: | Background The availability of complete genomic sequences for hundreds of organisms promises to make obtaining genome-wide estimates of substitution rates, selective constraints and other molecular evolution variables of interest an increasingly important approach to addressing broad evolutionary questions. Two of the programs most widely used for this purpose are codeml and baseml, parts of the PAML (Phylogenetic Analysis by Maximum Likelihood) suite. A significant drawback of these programs is their lack of a graphical user interface, which can limit their user base and considerably reduce their efficiency. |
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