Evolution of the <Emphasis Type="Italic">DAZ</Emphasis> gene and the <Emphasis Type="Italic">AZFc</Emphasis> region on primate Y chromosomes |
| |
| Authors: | Yueh-Hsiang Yu Yi-Wen Lin Jane-Fang Yu Werner Schempp Pauline H Yen |
| |
| Institution: | (1) Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan;(2) Institute of Biomedical Sciences, Academia Sinica, Taiwan;(3) Taipei Zoo, Taipei, Taiwan;(4) Institute of Human Genetics and Anthropology, University of Freiburg, Germany |
| |
| Abstract: | Background The Azoospermia Factor c (AZFc) region of the human Y chromosome is a unique product of segmental duplication. It consists almost entirely of very long
amplicons, represented by different colors, and is frequently deleted in subfertile men. Most of the AZFc amplicons have high sequence similarity with autosomal segments, indicating recent duplication and transposition to the Y
chromosome. The Deleted in Azoospermia (DAZ) gene within the red-amplicon arose from an ancestral autosomal DAZ-like (DAZL) gene. It varies significantly between different men regarding to its copy number and the numbers of RNA recognition motif
and DAZ repeat it encodes. We used Southern analyses to study the evolution of DAZ and AZFc amplicons on the Y chromosomes of primates. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
