Hyperthermia and the neurotoxicity of exogenous glutamate in infant rats |
| |
Authors: | Rafael Peñafiel Asunción Cremades Luis Puelles Francisco Monserrat |
| |
Affiliation: | 1. Department of Biochemistry, Faculty of Medicine, University of Murcia, Spain;2. Department of Pharmacology, Faculty of Medicine, University of Murcia, Spain;3. Department of Anatomy, Faculty of Medicine, University of Murcia, Spain |
| |
Abstract: | A substantial elevation of the excitatory neurotransmitter glutamate can be produced in the brain of 3-day old rats, either after subcutaneous injection of monosodium glutamate (4 mg/g), or by hyperthermic treatment (40°C, 3 h). In the glutamate-treated animals a large increase in the GABA levels has also been observed while the elevation of this amino acid in the hyperthermic animals is insignificant. Although the magnitude of the increase of glutamate in both cases is rather similar, in the hyperthermic animals no cerebral lesions such as those produced in the glutamate-treated animals could be observed. Therefore, high extracellular levels of glutamate seem to be required to produce the variety of neurotoxic effects related to this excitatory amino acid. |
| |
Keywords: | To whom correspondence should be sent: Dr R. Peñafiel Departamento Interfacultativo de Bioquímica Universidad de Murcia Murcia Spain. |
本文献已被 ScienceDirect 等数据库收录! |
|