Functional significance of the activities of glutaminase and ornithine-ω-aminotransferase in rat brain |
| |
Authors: | B Sadasivudu Zahida Nasreen M Swamy |
| |
Institution: | Centre for Advanced Research in Neurobiochemistry, Department of Biochemistry, Osmania Medical College, Hyderabad-500 001, Andhra Pradesh, India |
| |
Abstract: | The activities of glutaminase, glutamine synthetase (GS), arginase and ornithine amino transferase (orn-T) were studied in three regions of rat brain in heightened neuronal activity by producing convulsions by leptazol. These enzymes were studied in preconvulsive, convulsive and postconvulsive phases. Glutaminase activity was found to increase in all the three regions in the preconvulsive and convulsive phases. GS activity decreased in the preconvulsive phase but rose gradually to the control level when the postconvulsive phase was reached. The activity of arginase decreased in the cerebellum in preconvulsive and convulsive phases. However, in the cerebral cortex there was a decrease in the activity of this enzyme only in the convulsive phase. The results suggest that glutamine acts more likely as a precursor for the neurotransmitter pool of glutamate, while ornithine serves more as a precursor for the neurotransmitter pool of GABA. |
| |
Keywords: | Correspondence to be addressed to: Professor B Sadasivudu Department of Biochemistry M S Ramaiah Medical College Gokula Bangalore-560 054 India |
本文献已被 ScienceDirect 等数据库收录! |
|