| 三唑磷、氟虫腈及其复配剂对四种miRNAs在斑马鱼组织中表达的影响 |
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| 引用本文： | 张羽,王星星,周胜利,朱国念,丁先锋,郭江峰. 三唑磷、氟虫腈及其复配剂对四种miRNAs在斑马鱼组织中表达的影响[J]. 生物物理学报, 2011, 0(5): 403-409 |
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| 作者姓名： | 张羽 王星星 周胜利 朱国念 丁先锋 郭江峰 |
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| 作者单位： | 浙江理工大学生物工程研究所;浙江大学农药与环境毒理研究所; |
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| 基金项目： | “863”计划项目(2007AA02Z165)~~ |
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| 摘 要： | MicroRNAs(miRNAs)是一类长约22 nt的非编码小RNA,在基因表达中起重要调控作用.已有研究表明,农药三唑磷和氟虫腈能影响斑马鱼全鱼组织中部分miRNAs的正常表达,但未见对miRNA表达的组织特异性的研究.本研究采用荧光定量PCR技术研究了经三唑磷微乳剂、氟虫腈微乳剂及其复配剂处理后,四种miRNA(...
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| 关 键 词： | MicroRNA 氟虫腈 三唑磷 斑马鱼 荧光定量PCR |
Effects of Triazophos,Fipronil and Their Mixture on Expression of Four miRNAs in Zebrafish Tissues |
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| ZHANG Yu,WANG Xingxing,ZHOU Shengli,ZHU Guonian,DING Xianfeng,GUO Jiangfeng. Effects of Triazophos,Fipronil and Their Mixture on Expression of Four miRNAs in Zebrafish Tissues[J]. Acta Biophysica Sinica, 2011, 0(5): 403-409 |
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| Authors: | ZHANG Yu WANG Xingxing ZHOU Shengli ZHU Guonian DING Xianfeng GUO Jiangfeng |
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| Affiliation: | ZHANG Yu1,WANG Xingxing1,ZHOU Shengli2,ZHU Guonian2,DING Xianfeng1,GUO Jiangfeng1 1.Institute of Bioengineering,Zhejiang Sci-Tech University,Hangzhou 310018,China,2.Institute of Pesticide and Environmental Toxicology,Zhejiang University,Hangzhou 310029 |
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| Abstract: | MicroRNAs(miRNAs) are a class of small non-coding RNAs with the length of about 22 nt.It has been documented that miRNAs play an important role in regulation of gene expression.It is showed that the normal expression of partial miRNA in zebrafish tissues could be influenced by treatments of pesticide triazophos or fipronil,however,the tissues-specific miRNA expression has not been characterized yet.The expression changes of 4 miRNAs,namely miR-21,miR-128,miR-155 and miR-181a,in zebrafish brain and eye tissu... |
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| Keywords: | MicroRNA Triazophos Fipronil Zebrafish Real-time PCR |
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