Stabilization of stannous pyrophosphate kits with gentisic acid |
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| Institution: | 1. Normandie Univ, UNICAEN, CERMN, F-14032 Caen, France;2. Hôpitaux Universitaires de Genève, Département de Santé Mentale et de Psychiatrie, Service de Psychiatrie Générale, Unité des Biomarqueurs de Vulnérabilité, Chemin du Petit-Bel-Air, 2, CH-1225 Genève, Switzerland;1. Molecular Imaging and Therapeutic Nuclear Medicine, Peter MacCallum Cancer Centre, Melbourne, Australia;2. The Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia;1. Department of Kinesiology, Faculty of Applied Health Sciences, University of Waterloo, Waterloo, Ontario, N2L 3G1, Canada;2. Faculty of Kinesiology & Physical Education, University of Toronto, Toronto, Ontario, M5S 2W6, Canada;3. Canadian Memorial Chiropractic College, Department of Graduate Education & Research, Toronto, Ontario, M2H 3J1, Canada;1. Department of Chemical Engineering, M.S. Ramaiah Institute of Technology, Bangalore 560054, India;2. Department of Biotechnology, Basaveshwar Engineering College, Bagalkot 587102, India;1. School of Civil Engineering, North China University of Technology, Beijing 100144, China;2. Beijing Fayan Engineering Technology CO., LTD., Beijing 100102, China;3. China Institute of Water Resources and Hydropower Research, Beijing 100038, China |
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| Abstract: | We evaluated the ability of gentisic acid, an antioxidant, to stabilize stannous pyrophosphate (Sn:PPi) kits and extend the shelf-life of the kit after reconstitution. In vitro studies showed that gentisic acid (0.5 mg/mL) stabilized the stannous ion against oxidation by various levels of exogenous hydrogen peroxide. In patients who received stabilized Sn:PPi for in vivo red blood cell labelling, the left ventricle-to-background activity ratio was significantly higher than that in patients who received a standard formulation of Sn:PPi. Gentisic acid is now used routinely in the Sn:PPi kit formulation in this institution. |
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