Modulation of smooth muscle activity by excitatory and inhibitory nerves in the guinea-pig stomach |
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| Institution: | 1. Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany;2. Department of Physics, Humboldt University, Berlin, Germany;3. Bernstein Center for Computational Neuroscience Berlin, Berlin, Germany;1. Centre for Systems Modelling & Quantitative Biomedicine (SMQB), University of Birmingham, Birmingham, UK;2. Department of Pharmacology and Brehm Center for Diabetes Research, University of Michigan Medical School, Ann Arbor, Michigan;3. Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, Massachusetts;4. Laboratory of Biological Modeling, National Institutes of Health, Bethesda, Maryland;5. Institute for Mathematical Methods in Medicine and Data Based Modeling, Johannes Kepler University, Linz, Austria;6. Johann Radon Institute for Computational and Applied Mathematics (RICAM), Austrian Academy of Sciences, Linz, Austria;7. Department of Mathematics and Programs in Neuroscience and Molecular Biophysics, Florida State University, Tallahassee, Florida;1. Division of Gastroenterology, Northern Jiangsu People’s Hospital, Yangzhou, China;2. Division of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China;3. Division of Gastroenterology, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, China;4. Division of Intervention, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, China;5. Division of Gastroenterology, The Affiliated Huaian No. 1 People’s Hospital of Nanjing Medical University, Huaian, China;6. Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China;7. Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor, MI, USA |
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| Abstract: | - 1.1. In smooth muscle of the guinea-pig stomach, intramural nerve stimulation evoked cholinergic excitatory junction potential in the fundus and non-adrenergic non-cholinergic inhibitory junction potential in the antrum, yet cholinergic contractions in both regions.
- 2.2. This dissociation between electrical and mechanical responses was mainly due to different sensitivity of the membrane for depolarization to acetylcholine.
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