Autoradiographic localization of technetium-99 methylene diphosphonate in growth sites of young mice |
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| Affiliation: | 1. Forsyth Dental Center, 140 The Fenway, Boston, MA 02115, U.S.A.;2. Harvard School of Dental Medicine, 188 Longwood Avenue Boston, MA 02115, U.S.A.;3. Department of Radiology (Nuclear Medicine), Harvard Medical School, Shield Warren Radiation Laboratory, 50 Binet Street, Boston, MA 02115, U.S.A.;1. Institute for Energy Research, Jiangsu University, Zhenjiang, P.R. China;2. Department of Mechanical Engineering, Benha Faculty of Engineering, Benha University, Benha, Egypt;3. School of Food and Biological Engineering, Jiangsu University, Zhenjiang, P.R. China;4. Department of Botany and Microbiology, Faculty of Science, Tanta University, Tanta, Egypt;1. School of Public Health, The University of Queensland, Herston, QLD 4006, Australia;2. National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases, The Children’s Hospital at Westmead, Westmead, NSW 2145, Australia;3. Discipline of Child and Adolescent Health, University of Sydney, The Children’s Hospital at Westmead, Westmead, NSW 2145, Australia;4. UQ Child Health Research Centre, School of Medicine, The University of Queensland, Herston, QLD 4006, Australia;5. Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia;6. Departments of Infectious Disease and Paediatrics, Gold Coast Health, Gold Coast, QLD 4222, Australia;7. Communicable Diseases Branch, Queensland Health, Herston, QLD 4006, Australia;1. Key Laboratory of Water Environment Evolution and Pollution Control in Three Gorges Reservoir, School of Environmental and Chemical Engineering, Chongqing Three Gorges University, Chongqing, 404100, China;2. School of Metallurgy, Northeastern University, Shenyang, 110819, China;3. Department of Chemistry, Hong Kong Baptist University, Hong Kong, 999077, China;1. School of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel-Aviv, Israel;2. The Steinhardt Museum of Natural History, Israel National Center for Biodiversity Studies, Tel Aviv University, Tel-Aviv, Israel |
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| Abstract: | Conflicting reports about the localization of 99mTc-MDP in bone and cartilage are found in the literature. Possible binding sites include hydroxyapatite and non-osteoid matrix such as immature collagen. The present study used autoradiographs of demineralized and non-demineralized growth sites in young mice to demonstrate localization of 99Tc-MDP, and consequently 99mTc-MDP, in mineralizing cartilage and bone. Uptake of the isotope was seen in mineralizing bone and cartilage, associated with the mineral in contrast to the organic phase. The results indicate that bone seeking radiopharmaceutical uptake (BSRU) may detect alterations in the rate of mineralized phase in growth sites and thus has the potential to disclose skeletal growth disorders. |
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