Characterization of drug responses of the intestine of the house musk shrew (Suncus murinus) |
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| Affiliation: | 1. Department of Chemistry, College of Basic Sciences and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, 263145, U.S. Nagar, Uttarakhand, India;2. ICAR-Indian Grassland and Fodder Research Institute, Jhansi, 284003, Uttar Pradesh, India;3. Department of Plant Pathology, College of Agriculture, G.B. Pant University of Agriculture and Technology, Pantnagar, 263145, U.S. Nagar, Uttarakhand, India;4. Department of Biological Sciences, College of Basic Science and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, 263145, U.S. Nagar, Uttarakhand, India;5. Department of Biochemistry, College of Basic Science and Humanities, G.B. Pant University of Agriculture and Technology, Pantnagar, 263145, U.S. Nagar, Uttarakhand, India;6. Department of Botany, University of Delhi, New Delhi, 110007, India;7. Department of Botany, Aligarh Muslim University, Aligarh, 202002, India;1. Cotton leafworm Research Department, Plant Protection Research Institute. Agriculture Research Center, El-Nubaria Research Station, Egypt;2. Vegetable and Aromatic Plant Insects Research Department, Plant Protection Research Institute. Agriculture Research Center, El-Nubaria Research Station, Egypt;3. Cutworm and Mole Cricket Research Department, Plant Protection Research Institute, Agriculture Research Center, El-Nubaria Research Station, Egypt |
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| Abstract: | - 1.1. To characterize the pharmacological properties of the intestine of Suncus murinus, an Insectivora, the effects of drugs on the mechanical activity of the isolated intestine were examined.
- 2.2. The drugs examined include: (1) autonomie drugs such as acetylcholine, nicotine, norepinephrine, epinephrine and isoproterenol; (2) autacoids such as histamine and 5-hydroxytryptamine; (3) peptides such as bradykinin, thyrotropin releasing hormone and methionine-enkephalin.
- 3.3. The present study shows that the pharmacological responses of the intestine of Suncus murinus, especially to isoproterenol, histamine and peptides, have some properties distinct from those of rodents.
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