Effects of fasting on the myocardial subcellular distribution and lipid distribution of terminal p-iodophenyl-substituted fatty acids in rats |
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| Institution: | 1. Department of Electrical Engineering, Silicon Institute of Technology, Odisha, India;2. Department of Electrical and Electronics Engineering, Siksha ‘O’ Anusandhan University, Odisha, India;3. College of Engineering at Wadi Addawaser, Prince Sattam bin Abdulaziz University, 11991, Saudi Arabia;1. Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Pune 411008, India;2. Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, India;3. Division of Physical and Material Chemistry, CSIR-National Chemical Laboratory, Pune 411008, India;1. Department of Civil and Environmental Engineering, University of Waterloo, Waterloo, Ontario, Canada;2. Department of Earth and Environmental Sciences, University of Waterloo, Waterloo, Ontario, Canada;1. Key Laboratory of Gas and Fire Control for Coal Mines, Ministry of Education, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China;2. School of Safety Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China;3. State Key Laboratory of Coal Resources and Mine Safety, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China |
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| Abstract: | The myocardial lipid pool distribution and subcellular distribution of radiolabeled methyl-branched fatty acids in rats was evaluated under conditions of fasting (24 h) and feeding. With the unbranched iodophenyl fatty acid, fasting resulted in increased myocardial extraction and clearance time with a decrease in the incorporation into triglycerides and greater radioactivity in the mitochondrial fraction. With the monomethyl-branched analogue, the effects of fasting on lipid and subcellular distribution were minor except for a decrease in triglyceride incorporation. Like the unbranched analogue, the dimethyl-branched iodophenyl fatty acid showed increased myocardial extraction with fasting, however, this structurally-modified fatty acid showed increased rather than decreased incorporation into triglycerides. |
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