c-myc oncogene expression inhibits the initiation of myogenic differentiation |
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Authors: | N Denis S Blanc M P Leibovitch N Nicolaiew F Dautry M Raymondjean J Kruh A Kitzis |
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Institution: | Institut de Pathologie Moléculaire, Faculté de Médicine Cochin-Port-Royal, Paris, France. |
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Abstract: | The role of c-myc oncogene expression in myogenic differentiation has been established by transfecting rat myoblasts of the L6 cell line with plasmid pMT-myc, in which the c-myc coding sequences were under the control of the metallothionein I promoter. We observed that the constitutive expression of the exogenous c-myc gene inhibits muscular differentiation. A diminution of the endogenous c-myc gene expression occurs within the first 24 h after the transfer of the cells to a differentiating medium. This early decrease of c-myc expression is required for cell differentiation to occur. We have also observed that exogenous myc gene expression has no effect on endogenous myc expression. |
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