| Abstract: | Experiments on 12 dogs have shown that alterations in the intrasystemic parameters of histamine-diamine oxidase, serotonin-monoamine oxidase, adrenaline-noradrenaline and in the intersystemic patterns of adrenaline-histamine indicate the biological adaptation under conditions of embolism of aorta trifurcation induced by 3-hour occlusion. Alterations in the activity of the enzymes studied underlie the adaptational syndrome. During 6-hour occlusions the activity of monoamine oxidase was relatively decreased. Meanwhile the content of serotonin and noradrenaline remained at a high level. These amines might participate in the development of pronounced hypoxic impairments seen in the course of the observation period. It is recommended that adrenoblockers and inhibitors of synthesis of serotonin or serotonin-reactive structures may be used for correction of metabolic disorders. |
