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Effects of ochratoxin A metabolites on yeast phenylalanyl-tRNA synthetase and on the growth and in vivo protein synthesis of hepatoma cells |
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| Authors: | E.E. Creppy F.C. Størmer D. Kern R. Röschenthaler G. Dirheimer |
| Affiliation: | 1. Institut de Biologie Moléculaire et Cellulaire du CNRS, 15 rue René Descartes, 67084 Strasbourg France;2. Faculté de Pharmacie, Université Louis Pasteur, 67048 Strasbourg France;3. Department of Toxicology, National Institute of Public Health, Oslo 1 Norway;4. Institute of Microbiology, University of Muenster, D-4400 Muenster F.R.G. |
| Abstract: | The ochratoxin A (OTA) metabolite (4R)-4-hydroxyochratoxin A [4R)-OTA) inhibits the aminoacylation of phenylalanine tRNA catalyzed by phenylalanyl-tRNA synthetase (PheRS) with a Ki-value of 0.9 mM as compared to 1.3 mM for OTA. It also inhibits protein synthesis and cell growth in the same manner as OTA. Ochratoxin alpha (OT alpha) does not affect either protein synthesis or cell growth. |
| Keywords: | Ochratoxin Phenylalanyl-tRNA synthethase Hepatoma cells Protein synthesis OH-OTA hydroxyochratoxin A OTA ochratoxin A OTα ochratoxin α PheRS phenylalanyl-tRNA synthetase |
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