Kringle 5 peptide-albumin conjugates with anti-migratory activity |
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| Authors: | Léger Roger Benquet Corinne Huang Xicai Quraishi Omar van Wyk Pieter Bridon Dominique |
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| Affiliation: | Research Department, ConjuChem Inc., 225 President-Kennedy Ave., Suite 3950, Montréal, QC, H2X 3Y8 Canada. leger@conjuchem.com |
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| Abstract: | Three peptide fragments of the kringle 5 region of plasminogen and their respective N- and C-terminus maleimido derivatives conjugated to Cys34 of human serum albumin were evaluated in vitro using a human umbilical vein endothelial cell (HUVEC) migration assay and a human plasma stability assay. The N-terminus maleimido derivative of the 64 to 74 segment of kringle 5 conjugated to human serum albumin possessed remarkable anti-migratory activity. |
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