The matrix corroded: podosomes and invadopodia in extracellular matrix degradation |
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| Authors: | Linder Stefan |
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| Institution: | 1. Randall Division of Cell & Molecular Biophysics, King’s College London, Guy’s Campus, London SE1 1UL, UK;2. Cancer Division, King’s College London, Guy’s Campus, London SE1 1UL, UK;1. Department of Biology, Drexel University, United States;2. Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, United States;1. Department of Anatomy and Structural Biology, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, United States;2. Gruss Lipper Biophotonics Center, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, United States |
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| Abstract: | Podosomes and invadopodia are unique actin-rich adhesions that establish close contact to the substratum but can also degrade components of the extracellular matrix. Accordingly, matrix degradation localized at podosomes or invadopodia is thought to contribute to cellular invasiveness in physiological and pathological situations. Cell types that form podosomes include monocytic, endothelial and smooth muscle cells, whereas invadopodia have been mostly observed in carcinoma cells. This review highlights important new developments in the field, discusses the common and divergent features of podosomes and invadopodia and summarizes current knowledge about matrix-degrading proteinases at these structures. |
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