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Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives |
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| Authors: | Krueger A Chris Madigan Darold L Beno David W Betebenner David A Carrick Robert Green Brian E He Wenping Liu Dachun Maring Clarence J McDaniel Keith F Mo Hongmei Molla Akhteruzzaman Motter Christopher E Pilot-Matias Tami J Tufano Michael D Kempf Dale J |
| Affiliation: | Abbott Labs, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. a.chris.krueger@abbott.com |
| Abstract: | The synthesis of several pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays. |
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