Control of <Emphasis Type="Italic">gag-pol</Emphasis> gene expression in the <Emphasis Type="Italic">Candida albicans</Emphasis> retrotransposon Tca2 |
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| Authors: | Elaine M Forbes Siân R Nieduszynska Fiona K Brunton Joanne Gibson L Anne Glover Ian Stansfield |
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| Institution: | (1) School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK;(2) Dept. of Pediatrics, University of Arizona, College of Medicine, Tucson, AZ 85724, USA;(3) School of Medicine, King's College London, Strand, London, WC2R 2LS, UK |
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| Abstract: | Background In the C. albicans retrotransposon Tca2, the gag and pol ORFs are separated by a UGA stop codon, 3' of which is a potential RNA pseudoknot. It is unclear how the Tca2 gag UGA codon is bypassed to allow pol expression. However, in other retroelements, translational readthrough of the gag stop codon can be directed by its flanking sequence, including a 3' pseudoknot. |
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