Mosaicism of Solid Gold supports the causality of a noncoding A-to-G transition in the determinism of the callipyge phenotype |
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Authors: | Smit Maria Segers Karin Carrascosa Laura Garcia Shay Tracy Baraldi Francesca Gyapay Gabor Snowder Gary Georges Michel Cockett Noelle Charlier Carole |
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Institution: | Department of Animal, Dairy and Veterinary Sciences, College of Agriculture, Utah State University, Logan, Utah 84322-4700, USA. |
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Abstract: | To identify the callipyge mutation, we have resequenced 184 kb spanning the DLK1-, GTL2-, PEG11-, and MEG8-imprinted domain and have identified an A-to-G transition in a highly conserved dodecamer motif between DLK1 and GTL2. This was the only difference found between the callipyge (CLPG) allele and a phylogenetically closely related wild-type allele. We report that this SNP is in perfect association with the callipyge genotype. The demonstration that Solid Gold-the alleged founder ram of the callipyge flock-is mosaic for this SNP virtually proves the causality of this SNP in the determinism of the callipyge phenotype. |
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