| 巨噬细胞凋亡及其调控 |
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| 引用本文： | 黄行许,黄有国.巨噬细胞凋亡及其调控[J].生物化学与生物物理进展,2000,27(2):139-142. |
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| 作者姓名： | 黄行许 黄有国 |
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| 作者单位： | 中国科学院生物物理研究所,生物大分子国家重点实验室,北京,100101 |
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| 摘 要： | 巨噬细胞通过介导和调控自身及其他细胞凋亡而实现其免疫调节和效应细胞功能.引起巨噬细胞凋亡的原因有生物、化学、病理、自身等因素.不仅巨噬细胞自身凋亡和凋亡调控有其特点,更为有趣的是，巨噬细胞可根据需要：介导或抑制自身凋亡；介导或抑制其他细胞凋亡；抑制自身凋亡，介导其他细胞凋亡.这可能是巨噬细胞在免疫调节，特别是肿瘤免疫中发挥重要作用的基础.
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| 关 键 词： | 巨噬细胞，细胞凋亡，凋亡调控，免疫调节 |
| 收稿时间： | 2/3/1999 12:00:00 AM |
| 修稿时间： | 1999-02-03 |
Apoptosis and Its Regulation of Macrophage |
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| HUANG Xing-Xu and HUANG You-Guo.Apoptosis and Its Regulation of Macrophage[J].Progress In Biochemistry and Biophysics,2000,27(2):139-142. |
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| Authors: | HUANG Xing-Xu and HUANG You-Guo |
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| Institution: | National Laboratory of Biomacromolecules, Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China;National Laboratory of Biomacromolecules, Institute of Biophysics, The Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | By mediating and regulating of apoptosis in macrophages themselves and other cells as well, macrophages carry out their function in immunology and immunological regulation. The macrophage apoptosis inducing factors were of biologic, chemical, pathologic. Some distinguished features characterized macrophage apoptosis and its regulation. Interestingly, to fit in with need of the body, macrophages may mediate or inhibit apoptosis in themselves, favour or inhibit apoptosis of other cells, inhibit apoptosis in themselves and favoured apoptosis of others, which may be the base for macrophages play a role in immunological regulation, especially in tumor immunology. |
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| Keywords: | macrophage apoptosis apoptosis regulation immunological regulation |
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