Evaluation of an in silico predicted specific and immunogenic antigen from the OmcB protein for the serodiagnosis of Chlamydia trachomatis infections |
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| Authors: | Olfa Frikha-Gargouri Radhouane Gdoura Abir Znazen Boutheina Gargouri Jalel Gargouri Ahmed Rebai Adnene Hammami |
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| Affiliation: | (1) Department of Microbiology and research laboratory "Microorganismes et Pathologie Humaine", Habib Bourguiba hospital of Sfax, Tunisia;(2) Department of blood bank, Sfax, Tunisia;(3) Bioinformatics Unit, Centre of Biotechnology of Sfax, Tunisia |
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| Abstract: | Background The OmcB protein is one of the most immunogenic proteins in C. trachomatis and C. pneumoniae infections. This protein is highly conserved leading to serum cross reactivity between the various chlamydial species. Since previous studies based on recombinant proteins failed to identify a species specific immune response against the OmcB protein, this study evaluated an in silico predicted specific and immunogenic antigen from the OmcB protein for the serodiagnosis of C. trachomatis infections. |
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