Light-triggered conversion of non-ionic into ionic surfactants: towards chameleon detergents for 2-D gel electrophoresis |
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| Authors: | Bogen Oliver Milosevic Petar Daroszi Hans Dreger Mathias Hecht Stefan Hucho Ferdinand |
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| Affiliation: | Institut für Chemie-Biochemie, Freie Universit?t Berlin, Berlin, Germany. |
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| Abstract: | Caged non-ionic detergents, comprised of polar oligo(ethylene glycol) and non-polar alkyl chains joined by a photocleavable ortho-nitrobenzyl sulfonate linker have been synthesized and characterized. The light-triggered transformation of such chameleon surfactant from a charge-neutral into a charged form offers great potential to improve 2-D gel electrophoretic separation of complex protein mixtures. |
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