Impaired angiogenesis in neuropeptide Y (NPY)-Y2 receptor knockout mice |
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Authors: | Lee Edward W Grant Derrick S Movafagh Sharareh Zukowska Zofia |
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Affiliation: | Department of Physiology & Biophysics, Georgetown University Medical Center, 3900 Reservoir Road, NW, BSB 234, Washington, DC 20007, USA. leeew@georgetown.edu |
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Abstract: | Which of Y1-Y5 receptors (Rs) mediate NPY's angiogenic activity was studied using Y2R-null mice and R-specific antagonists. In Y2R-null mice, NPY-induced aortic sprouting and in vivo Matrigel capillary formation were decreased by 50%; Y1R-antagonist blocked the remaining response. NPY-induced sprouting was equally inhibited by Y2R- (and Y5R- but less by Y1R-) antagonists in wild type mice. Spontaneous and NPY-induced revascularization of ischemic gastrocnemius muscles were similarly reduced in Y2R-null mice. Thus, NPY-induced angiogenesis, spontaneous and ischemic, is primarily mediated by Y2Rs. However, Y5Rs and, to a lesser degree Y1Rs, also may play a role in NPY-mediated angiogenesis. |
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