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Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration
Authors:Filipa F Vale   Francis Mégraud  Jorge MB Vítor
Affiliation:(1) Engineering Faculty, Portuguese Catholic University, Estrada Oct?vio Pato, 2635-631 Rio de Mouro, Portugal;(2) INSERM U853, F 33076 Bordeaux, France;(3) iMed.UL (MedChem Division), Faculty of Pharmacy, University of Lisbon, Av. das For?as Armadas, 1649-003 Lisboa, Portugal
Abstract:

Background  

Helicobacter pylori colonizes the human stomach and is associated with gastritis, peptic ulcer, and gastric cancer. This ubiquitous association between H. pylori and humans is thought to be present since the origin of modern humans. The H. pylori genome encodes for an exceptional number of restriction and modifications (R-M) systems. To evaluate if R-M systems are an adequate tool to determine the geographic distribution of H. pylori strains, we typed 221 strains from Africa, America, Asia, and Europe, and evaluated the expression of different 29 methyltransferases.
Keywords:
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