Stratification of co-evolving genomic groups using ranked phylogenetic profiles |
| |
| Authors: | Shiri Freilich Leon Goldovsky Assaf Gottlieb Eric Blanc Sophia Tsoka Christos A Ouzounis |
| |
| Affiliation: | (1) The Blavatnik School of Computer Sciences and School of Medicine, Tel-Aviv University, 69978 Tel-Aviv, Israel;(2) Computational Genomics Unit, Institute of Agrobiotechnology,Centre for Research & Technology Hellas,(CERTH), GR-57001 Thessalonica, Greece;(3) School of Physics and Astronomy,Tel-Aviv University, Tel-Aviv, 69978, Israel;(4) King's College Centre for Bioinformatics (KCBI),School of Physical Sciences & Engineering,King's College London, Strand,London, WC2R 2LS, UK;(5) MRC Centre for Developmental Neurobiology, New Hunt's House,King's College London,Guy's Campus, London, Uk |
| |
| Abstract: | Background Previous methods of detecting the taxonomic origins of arbitrary sequence collections, with a significant impact to genome analysis and in particular metagenomics, have primarily focused on compositional features of genomes. The evolutionary patterns of phylogenetic distribution of genes or proteins, represented by phylogenetic profiles, provide an alternative approach for the detection of taxonomic origins, but typically suffer from low accuracy. Herein, we present rank-BLAST, a novel approach for the assignment of protein sequences into genomic groups of the same taxonomic origin, based on the ranking order of phylogenetic profiles of target genes or proteins across the reference database. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
