Conversion of a polysaccharide to nitric oxide-releasing form. Dual-mechanism anticoagulant activity of diazeniumdiolated heparin |
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| Authors: | Saavedra J E Mooradian D L Mowery K A Schoenfisch M H Citro M L Davies K M Meyerhoff M E Keefer L K |
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| Affiliation: | Intramural Research Support Program, SAIC Frederick, NCI-FCRDC, MD 21702, USA. |
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| Abstract: | We describe heparin/diazeniumdiolate conjugates that generate nitric oxide (NO) at physiological pH. Like the heparin from which they were prepared, they inhibit thrombin-induced blood coagulation. Unlike heparin, they can also inhibit and reverse ADP-induced platelet aggregation (as expected for an NO-releasing agent), suggesting potential utility as dual-action antithrombotics. |
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