Gen(om)e duplications in the evolution of early vertebrates |
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Authors: | Arend Sidow |
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Affiliation: | Whitehead Institute, 9 Cambridge Center, Massachusetts 02142, USA |
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Abstract: | Phylogenetic analyses and sequence surveys of developmental regulator gene families indicate that two large-scale gene duplications, most likely genome duplications, occurred in ancestors of vertebrates. Relaxed constraints allowed duplicated and thus redundant genes to diverge in a two stage mechanism. Neutral changes dominated at first but then positively selected regulatory changes evolved the novel and increasingly complex vertebrate developmental program. |
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Keywords: | Abbreviations: CNS central nervous system Fgf fibroblast growth factor lgf insulin-like growth factor |
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