Interactions of La3+ and local anesthetic drugs with mitochondrial Ca++ and Mn++ uptake |
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| Authors: | L Mela |
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| Affiliation: | 1. CNR ISSMC - Institute of Science, Technology and Sustainability for Ceramics (former ISTEC), Via Granarolo 64, 48018, Faenza, (RA), Italy;2. HiLASE Centre, Institute of Physics of the Czech Academy of Sciences, V.v.i., Za Radnicí 828, 25241, Dolní Břežany, Czech Republic;3. Institute for Single Crystals of NAS of Ukraine, 60 Nauky Ave., Kharkiv, 61072, Ukraine;1. Department of Physics, Renmin University of China, Beijing 100872, China;2. Songshan Lake Materials Laboratory, Dongguan 523808, Guangdong, China.;3. Beijing National Laboratory for Condensed Matter Physics and Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China;4. Dongguan Academy of Advanced Ceramics and Composite Materials, Dongguan 523722, China;1. PSL Research University, Chimie ParisTech, CNRS, Institut de Recherche de Chimie Paris, 75005, Paris, France;2. Sorbonne Universités, UPMC Univ Paris 06, 75005, Paris, France;3. Department of Physics, Montana State University, Bozeman, MT, 59717, USA;4. Laboratoire Aimé Cotton UMR 9188, CNRS, Université Paris-Sud, ENS Cachan, Université Paris-Saclay, Bâtiment 505, Campus Universitaire, 91405, Orsay, France;1. Key Laboratory of Transparent Opto-functional Inorganic Materials, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, China;2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China;3. Istituto Nazionale di Ottica, Consiglio Nazionale delle Ricerche, CNR-INO, Via Madonna del Piano 10C, 50019, Sesto Fiorentino (Fi), Italy;4. Istituto di Fisica Applicata “Carrara”, Consiglio Nazionale delle Ricerche, CNR-IFAC, Via Madonna del Piano 10C, 50019, Sesto Fiorentino (Fi), Italy;5. School of Material Science and Engineering, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, China;1. Integrated Nanotechnology Research Center (INRC), Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen, 40002, Thailand;2. National Metal and Materials Technology Center, 114 Thailand Science Park, Paholyothin Rd. Klong 1, Klong Luang, Pathunthani, 12120 Thailand;3. Synchrotron Light Research Institute (Public Organization), 111 University Avenue, Muang District, Nakhon Ratchasima, 30000, Thailand;4. School of Physics, Institute of Science, Suranaree University of Technology, Nakhon Ratchasima, 30000, Thailand |
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| Abstract: | Interactions of lanthanum and some local anesthetic drugs with divalent cation uptake have been studied in rat liver mitochondria. The oxidation-reduction changes of the respiratory chain components and the development of the membrane pH gradient were measured during ion uptake. The trivalent ion lanthanum was found to be a powerful inhibitor of divalent cation uptake with half-maximal effect observed at concentrations of approximately 0.1 mμmole La3+/mg protein. The neurotropic drugs butacaine, dibucaine, chlorpromazine, and phenergan enhanced remarkably the divalent cation-induced membrane pH gradient. The possible mechanism of the action of lanthanum and local anesthetics ou mitochondrial membranes is discussed. |
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