Mutagenicity of oxaspiro compounds with Salmonella |
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Authors: | J E Sinsheimer P K Chakraborty E A Messerly V Gaddamidi |
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Affiliation: | College of Pharmacy, University of Michigan, Ann Arbor 48109-1065. |
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Abstract: | The spiro attachment of an epoxide group to a tetrahydropyran ring in the trichothecene mycotoxins has prompted this study of the mutagenicity and alkylation rates of the trichothecene, anguidine, and 5 related model oxaspiro compounds. While the model compounds were weak alkylating agents of 4-(4-nitrobenzyl)pyridine as a test nucleophile, anguidine lacks such activity. Also, while mutagenicity was not established for anguidine in Salmonella TA100, 3 of the oxaspiro compounds were weakly mutagenic and 2 compounds were toxic to the bacteria. The toxicity and mutagenicity of the model compounds are more related to their polarity than to their alkylation rates. |
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