1H, 13C, 15N and 31P chemical shift assignments of a human Xist RNA A-repeat tetraloop hairpin essential for X-chromosome inactivation |
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| Authors: | Malgorzata M. Duszczyk Michael Sattler |
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| Affiliation: | (1) Institute of Structural Biology, Helmholtz Zentrum M?nchen, Ingolst?dter Landstr. 1, 85764 Neuherberg, Germany;(2) Biomolecular NMR and Center for Integrated Protein Science Munich at Department Chemie, Technische Universit?t M?nchen, Lichtenbergstr. 4, 85747 Garching, Germany; |
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| Abstract: | Initiation of X-chromosome inactivation in female mammals depends on the non-coding RNA Xist. We have solved the NMR structure of a 14-nucleotide hairpin with a novel AUCG tetraloop fold from a Xist A-repeat that is essential for silencing. The 1H, 13C, 15N and 31P chemical shift assignments are reported. |
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